Saturday, September 20, 2008

more with HyperChem adamantane and nucleic acids

I figured I better post more right away or else my signature MTF could suffer a credibility hit. Here is a POV-Ray trace of an adamantane molecule bonded to the 3' end of a short piece of ssDNA. I have been wondering about the wet chemistry necessary to pull something like this off, connecting to the oxygen (as shown) or to the phosphorous atom. I'm waiting to hear Guy's views on the subject, but if anyone else has some ideas, I would like to hear about them too.

(click for larger pic)

MTF

2 comments:

The Guy said...

To be honest, I'm still formulating a response. Trying to decide if the chemistry would be easier post oligonucleotide assembly or as the component of a modified amino acid pre-assembly. I've never studied diamondoid before but I'm taking it that adamantane is the minimum size chunk of diamond you can work with and still call it diamond? Has anyone established chemical routes to stable molecular adamantane? If so are there modified (radicalized) versions? What are their solubilities? If there's an adamantan-ol then it shouldn't be too hard to condense it with an amino acid, maybe guanine. Although that is an easier chemical path to getting the adamantane attached to the amino it probably isn't going to go well with PCR or sequence building. But it might.

So,,, I'm still thinkin' about it.

The Guy said...

Finally had a couple minutes to look up adamantane at wikipedia and am delighted to say that I see no serious chemical restriction to your current usage. I think the oxygen bond is more stable and easier to produce/accommodate. I even think it will be possible to bond to a nucleic acid and use in PCR. Which will make non-replicator type mass manufacturing much easier, thus overcoming one of the major objections of those who site runaway replication as a reason to avoid nanotech development.