tag:blogger.com,1999:blog-3060898714439566244.post1558361828609080543..comments2023-09-24T02:48:04.862-07:00Comments on Machine Phase: possible reaction for attaching adamantane to 5 prime end of DNATomhttp://www.blogger.com/profile/01639800769521054448noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-3060898714439566244.post-59478931491204592972008-10-03T01:07:00.000-07:002008-10-03T01:07:00.000-07:00I've been thinking about that too. I did find ...I've been thinking about that too. I did find one paper about sticking adamantane in the major groove. You can just copy and paste that link, trust me.<BR/><BR/>http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6THS-45S47K5-5&_user=1111158&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_version=1&_urlVersion=0&_userid=1111158&md5=95c454b3ee659f848cbcab47d6463bc1<BR/><BR/>Chemosabe, HA!Tomhttps://www.blogger.com/profile/01639800769521054448noreply@blogger.comtag:blogger.com,1999:blog-3060898714439566244.post-67894299627604593832008-10-02T19:43:00.000-07:002008-10-02T19:43:00.000-07:00Sorry about the Engrish, gotta proof-read more oft...Sorry about the Engrish, gotta proof-read more often.Guyhttps://www.blogger.com/profile/12623342498696677919noreply@blogger.comtag:blogger.com,1999:blog-3060898714439566244.post-13292929122642987432008-10-02T19:41:00.000-07:002008-10-02T19:41:00.000-07:00Hold your horses, Chemosabe.A little play on lone-...Hold your horses, Chemosabe.<BR/><BR/>A little play on lone-ranger terminology there.<BR/><BR/>Are you try to use the adamantane as a tool, or are you trying to deposit it? If the first, then your chemistry is adequate for the moment. But in the second case you will probably want to avoid all sorts of covalent bonding altogether and go with making a DNA "crook" that fits the adamantane and hold it there with electrostatics, van-der-walls or hydrogen bonding. Then use an enzyme or other reactive site to "weld" the adamantane in place.<BR/><BR/>On a side note, I've been giving thought to a Cartesian coordinate system (akin to that used by reprap http://www.reprap.org for its deposition system) as a significant necessity on the path to MNT. <BR/><BR/>Nice chem pics, by the way.Guyhttps://www.blogger.com/profile/12623342498696677919noreply@blogger.com